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This resulted in lower adherence of monocytes to endothelial cells of the thoracic aorta compared to the control group by downregulating adhesion molecules such as ICAM-1 and VCAM-1

Current guidance from the North American Menopause Society emphasizes personalized therapy with individualized dosing, route selection (considering transdermal to mitigate venous thromboembolism risk), and duration with periodic reevaluation

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Nasal spray risks include mucosal irritation, unknown systemic absorption levels leading to either underdosing or unpredictable dosing, and preservative-related side effects

pmid:22560220